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- MPS disease information
黏多醣儲積症疾病的背景資料 - How GAG accumulation affects cartilage
黏多醣體-葡萄糖胺聚合醣儲積如何影響軟骨 - Hip dysplasia in MPS
黏多醣儲積症引起的髖關節發育不良 - Spinal deformities in MPS
黏多醣儲積症引起的脊椎變異 - Ribs and shoulders in MPS
黏多醣儲積症引起的肋骨和肩膀問題 - Hand and other bone deformities in MPS
手和其他骨骼異常 - Non-skeletal manifestations of MPS
黏多醣儲積症其他非骨骼系統的表徵 - Diagnostic dilemma
診斷難題
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How GAG accumulation affects cartilage
Effects of GAGs in bone and cartilage
- GAG is an important component of extracellular matrix, synovial fluid, and connective tissues
- Excessive GAG levels are detrimental
- GAG accumulation in cartilage affects:
- Bone development1,2
- Formation of epiphyseal plates1–3
- Osteoclast activity3
- Aldenhoven M, et al. Ann Rheum Dis 2009;68:1659–1665.
- Oussoren E, et al. Biochim Biophys Acta 2011;1812(11):1542–1556.
- Clarke LA. Rheumatology 2011;50:v13–v16.
- Scanlon VC. Embryonic growth of bone. In Essentials of Anatomy and Physiology, 6th Ed, 2011.
- White KK. Rheumatology 2011;50:v26–v33.